Post-consumer resin dossiers require dual GC-HRMS and LC-HRMS screening with response-factor modeling to establish NIAS toxicological thresholds below 10 ppb.
Standardized NIAS calibration in PET relies on surrogate matrix-matched standards, response factor thresholds, and verified limits of detection below ten parts per billion.
Screening unknown volatile migrants demands thermal liberation, high-resolution spectral deconvolution, worst-case mass balance, and toxicological hazard assignment against threshold limits.
Unidentified migrants in food-contact PET above 10 ppb require structural elucidation, Cramer classification, or mutagenicity testing to establish safety.
Ionization efficiency matrix corrections convert high-resolution mass spectrometry peak areas into accurate migrant concentrations, preventing false compliant packaging declarations.
High-resolution mass spectrometry non-target screening identifies toxicologically uncharacterized polyolefin migrants down to sub-10 ppb compliance thresholds.
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